REVIEW: EFEKTIFITAS FASE GERAK PADA KUANTIFIKASI PARASETAMOL DAN KAFEIN SECARA SIMULTAN DENGAN RP-HPLC

Rusmalina, Siska and Khasanah, Kharismatul and Afaf, Afaf REVIEW: EFEKTIFITAS FASE GERAK PADA KUANTIFIKASI PARASETAMOL DAN KAFEIN SECARA SIMULTAN DENGAN RP-HPLC.

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Abstract

Combination drugs contain at least two types of active substances whose role is to combine therapeutic activities, increasing the potency and action of the drug, so that it can reduce the intensity of pain more quickly. and minimize side effects. Paracetamol and caffeine is a combination drug commonly used in therapy to relieve headaches or migraines, available in various brand names such as Panadol Extra, Paramex, and Saridon. The content of both in pharmaceutical preparations varies with a smaller caffeine concentration in each tablet/caplet/capsule. The problem with analysis using the spectrophotometric method is overlapping spectra, and the HPLC method overcomes this problem. Related articles published in the period 2016 - 2022 discuss both qualitative and quantitative analysis issues. Starting from the diversity of solvents used on samples and the use of mobile phase compositions for elution of compound mixtures which produce several variations in results. Researchers are interested in reviewing articles about the effectiveness of the mobile phase in determining the levels of a combination of paracetamol and caffeine in mixed preparations using the HPLC method. This research is a literature review. Search for articles on Google Scholar, Cochrane central, PubMed.gov databases via the National Library of Medicine and PMC via NCBI access. Some of the keywords used are simultaneous paracetamol and caffeine, HPLC/HPLC, analysis of paracetamol and caffeine levels. Keywords are combined using Indonesian and English using the conjunction "AND/AND". The search strategy was limited to publication years 2016-2022; National journals, national ones with the SINTA index, international journals, and international journals with the SCOPUS index; as well as full text articles. The effective mobile phase for simultaneous analysis of paracetamol and caffeine using the RP-HPLC method from the results of journal reviews in the 2016-2022 period is Methanol: Water (40:60 v/v), at a speed of 0.8-1.0 mL/ minute. These conditions produce separation that is classified as good, with a resolution value of >1.5. Paracetamol retention time 2.6-3.4 minutes. Caffeine in the 3.5-4.1 minute range. The effective time for simultaneous analysis of paracetamol and caffeine is 6.5 minutes.

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